このゲームは「オープンな戦闘」を提供し、プレイヤーに単人ミッションへのアプローチ方法に関するより多くの選択肢を与えます。マカロフが新しいキャンペーンの主悪役として登場します。 新しく導入されたCarry Forwardシステムにより、プレイヤーはModern Warfare IIから進捗状況とインベントリを保持できます。マルチプレイファンは、発売時に16マップ、その後少なくとも12マップを期待できます。ゾンビモードも復活し、これまでで最大のゾンビマップを提供する予定です。

The third entry in the rebooted Modern Warfare saga picks up in 2023, as the world edges toward another global conflict. Vladimir Makarov, a fanatical Russian ultranationalist and terrorist, has spent years imprisoned in a Kastovian penal complex after being captured following a devastating attack in Verdansk. When operatives of the shadowy Konni Group storm the prison and break him free, Makarov immediately resumes his campaign of terror, scheming to ignite a third World War and reshape the global order through calculated atrocities. Alerted to his escape by CIA station chief Kate Laswell, Captain John Price rallies the elite special forces of Task Force 141, including Soap, Ghost, and Gaz, to hunt the terrorist down before his plans can unfold. As Makarov sets a chain of attacks in motion across the globe, 141 must forge uneasy alliances and race across continents to stop him and avert catastrophe.